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February 1, 1996Arteriosclerosis Thrombosis and Vascular Biology

Deletion Polymorphism in the Angiotensin-Converting Enzyme Gene in Patients With a History of Ischemic Stroke

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Why the study?

Is the deletion polymorphism of the ACE gene (DD genotype) associated with a history of ischemic stroke?

Population

210 subjects attending a metabolic ward, comprising 101 with a history of ischemic stroke and 109 without.

Comparison

Deletion polymorphism of the ACE gene vs Absence of the DD genotype

Design

Case-control

Authors

MMMaurizio MargaglioneUniversity of FoggiaECEgidio CelentanoIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale"EGElvira GrandoneVascular Medicine

Discussion

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Implication

ACE DD genotype associated with prior ischemic stroke; hypothesis-generating and requires prospective confirmation before any clinical role.

Structured PICO

Is the deletion polymorphism of the ACE gene (DD genotype) associated with a history of ischemic stroke?

P
Population
210 subjects attending a metabolic ward, comprising 101 with a history of ischemic stroke and 109 without.
I
Intervention
Deletion polymorphism of the ACE gene (DD genotype)
C
Comparator
Absence of the DD genotype
O
Outcome
History of ischemic strokehard clinical

Homozygosity for a deletion polymorphism of the ACE gene (DD genotype) is independently associated with a history of ischemic stroke.

Cite This Study

Margaglione et al. (1996) studied this question.

synapsesocial.com/papers/6a911eb9b24842dac47a76cfhttps://doi.org/10.1161/01.atv.16.2.304
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Myocardial Infarction but Not With Development of Coronary Stenosis1995 · 175 citations
  2. 2Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.1994 · 229 citations
  3. 3Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes1993 · 516 citations
  4. 4PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)1992 · 1,250 citations
  5. 5Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Evidence of a potential interaction between the renin-angiotensin system and fibrinolytic function.1993 · 406 citations