Why the study?
Is the ACE gene insertion/deletion polymorphism associated with a parental history of stroke in hypertensive patients?
Population
70 hypertensive patients, mean age 59 +/- 11 years, with or without parental history of stroke before 60…
Comparison
ACE gene insertion/deletion polymorphism vs Patients without parental history of stroke /…
Design
Cross-sectional
Authors
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Supports ACE DD link to familial stroke in hypertension; hypothesis-generating, requires prospective validation before clinical use.
Is the ACE gene insertion/deletion polymorphism associated with a parental history of stroke in hypertensive patients?
The DD genotype of the ACE gene is associated with a parental history of stroke in hypertensive patients, independent of blood pressure levels or cardiac hypertrophy.
Maeda et al. (1996) studied this question.
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