Why the study?
Does the ACE DD genotype increase the risk of essential hypertension in Japanese subjects?
Population
5,014 Japanese subjects randomly selected from the general population (the Suita Study)
Comparison
Homozygous deletion polymorphism of the… vs ACE II genotype
Design
Cross-sectional
Authors
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ACE DD genotype associated with hypertension odds in Japanese men only; extends male-specific Framingham link to East Asians but leaves clinical adoption open.
Does the ACE DD genotype increase the risk of essential hypertension in Japanese subjects?
The ACE DD genotype is a genetic risk factor for essential hypertension in Japanese men, extending previous findings from white populations to an East Asian cohort.
Higaki et al. (2000) studied this question.
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