May 12, 1998Circulation
Variation in the Region of the Angiotensin-Converting Enzyme Gene Influences Interindividual Differences in Blood Pressure Levels in Young White Males
Why the study?
Does genetic variation in the renin-angiotensin system gene regions influence interindividual differences in blood pressure levels in young individuals?
Population
1488 siblings from 583 randomly ascertained three-generation pedigrees from Rochester, Minn.
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Suggests sex-specific genetic BP effects in youth; hypothesis-generating and should not yet change practice or guidelines.
Structured PICO
Does genetic variation in the renin-angiotensin system gene regions influence interindividual differences in blood pressure levels in young individuals?
P
Population
1488 siblings (mean age 14.8 years) from 583 randomly ascertained three-generation pedigrees from Rochester, Minn.
I
Intervention
Genetic variation in four renin-angiotensin system gene regions (angiotensinogen, renin, angiotensin I-converting enzyme, and angiotensin II receptor type 1)
O
Outcome
Interindividual variation in systolic, diastolic, and mean arterial pressuresurrogate
Genetic variation in the ACE gene region significantly influences interindividual blood pressure variability in a sex-specific manner, particularly in young males.
Cite This Study
Fornage et al. (1998) studied this question.