Context-Dependent Associations of the ACE I/D Polymorphism With Blood Pressure
Why the study?
Does the ACE I/D polymorphism influence blood pressure levels depending on gender, age, and body size in a general population?
Population
1875 non-Hispanic white individuals between 5 and 90 years of age from the general population of Rochester…
Comparison
ACE I/D polymorphism genotypes vs Comparison among different ACE genotypes
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
ACE I/D–BP associations vary by demographics; hypothesis-generating and should not yet change practice.
Structured PICO
Does the ACE I/D polymorphism influence blood pressure levels depending on gender, age, and body size in a general population?
P
Population
1875 non-Hispanic white individuals (988 female and 887 male subjects) between 5 and 90 years of age from the general population of Rochester, Minn.
I
Intervention
ACE I/D polymorphism genotypes
C
Comparator
Comparison among different ACE genotypes (II, I/D, DD)
O
Outcome
Blood pressure level (systolic and diastolic) and diagnostic category (hypertension versus normotension)surrogate
The association between the ACE I/D polymorphism and blood pressure is not uniform but depends significantly on demographic and anthropometric contexts such as age, gender, and body size.
Cite This Study
Turner et al. (1999) studied this question.