Why the study?
Do gene polymorphisms of the renin-angiotensin system modulate age-related changes in systolic and diastolic blood pressure in hypertensive subjects > 50 years of age?
Do gene polymorphisms of the renin-angiotensin system modulate age-related changes in systolic and diastolic blood pressure in hypertensive subjects > 50 years of age?
The ACE gene polymorphism, specifically the D allele, appears to modulate the age-induced reduction of diastolic blood pressure in hypertensive men over 50 years of age.
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ACE D allele was associated with steeper age-related diastolic BP decline in hypertensive men >50; hypothesis-generating and should not yet change practice.
A. Rudnichi (2004) studied this question.
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