The Purkinje network plays a role in modulating action potential morphology and transmural repolarization heterogeneity in both healthy and failing myocardium.
The Purkinje network has the potential to influence myocardial AP morphology and rate-dependent behaviour, and furthermore to underlie enhanced transmural APD heterogeneities and spatial gradients of APD in non-failing and failing myocardium.
Walton et al. (Thu,) studied this question.