The Purkinje network plays a role in modulating action potential morphology and transmural repolarization heterogeneity in both healthy and failing myocardium.
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Should not alter clinical practice; leaves open Purkinje contributions to human repolarization heterogeneity.
The Purkinje network has the potential to influence myocardial AP morphology and rate-dependent behaviour, and furthermore to underlie enhanced transmural APD heterogeneities and spatial gradients of APD in non-failing and failing myocardium.
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Walton et al. (2014) studied this question.
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