Do non-cardiac comorbidities impact quality of life and mortality in patients with HFrEF, HFmrEF, and HFpEF?
Non-cardiac comorbidities are highly prevalent in HFpEF and significantly worsen quality of life and mortality, with specific impacts varying by heart failure subtype.
The highest prevalence of comorbidities was seen in patients with HFpEF. Overall, comorbidities were associated with a lower QoL, but this was more pronounced in patients with HFrEF. Most comorbidities were associated with higher mortality risks, although the associations with diabetes were only present in patients with HFrEF.
Streng et al. (Sat,) studied this question.
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