Does aspirin therapy reduce cardiovascular events in women and men for primary prevention?
In primary prevention, aspirin reduces cardiovascular events with sex-specific benefits (ischemic stroke in women, MI in men) but significantly increases bleeding risk in both sexes.
For women and men, aspirin therapy reduced the risk of a composite of cardiovascular events due to its effect on reducing the risk of ischemic stroke in women and MI in men. Aspirin significantly increased the risk of bleeding to a similar degree among women and men.
Berger et al. (Tue,) studied this question.