Long-term prognostic significance of negative CT-derived fractional flow reserve in patients with stable CAD: A meta-analysis of reconstructed time-to-event data | Synapse
April 8, 2026Open Access
Long-term prognostic significance of negative CT-derived fractional flow reserve in patients with stable CAD: A meta-analysis of reconstructed time-to-event data
Key Points
This research aims to assess the long-term prognostic value of negative CT-derived fractional flow reserve in patients with stable coronary artery disease.
Conducted a meta-analysis of reconstructed time-to-event data
Included patients with stable coronary artery disease
Analyzed rates of MACE-free survival
Assessed the implications of CT-FFR >80
Patients with CT-FFR >80 show high rates of long-term MACE-free survival
Negative CT-FFR indicates lower need for invasive evaluations.
Findings support safe deferral from interventions in selected patients.
Abstract
Patients with stable CAD and CT-FFR >80 can be safely deferred from invasive evaluations in the absence of other indications, due to their high rates of long-term MACE-free survival.