Compartment-specific GLUT1 patterns in colorectal liver metastases: invasive-margin GLUT1 associates with outcome in solitary disease

Key Points

• This research aims to explore how GLUT1 expression in different compartments of colorectal liver metastases (CRLM) relates to patient outcomes.
• Analyzed GLUT1 expression patterns in tumor-core and invasive-margin regions of CRLM using immunofluorescence.
• Examined the relationship between GLUT1 expression and patient outcomes in solitary metastases.
• Proposed further validation through quantitative spatial immune profiling and independent cohorts.
• Found a link between tumor-core GLUT1 and tumor proliferation.
• Identified invasive-margin GLUT1 as a marker associated with favorable patient outcomes in solitary metastases.
• Highlights the need for further quantitative analysis to confirm findings.