Does the addition of FFR-guided complete revascularization of non-infarct-related arteries in the acute setting reduce a composite cardiovascular outcome in patients with STEMI and multivessel disease who underwent primary PCI?
In STEMI patients with multivessel disease, performing FFR-guided complete revascularization in the acute setting reduces composite cardiovascular outcomes, primarily by decreasing the need for subsequent revascularizations.
In patients with STEMI and multivessel disease who underwent primary PCI of an infarct-related artery, the addition of FFR-guided complete revascularization of non-infarct-related arteries in the acute setting resulted in a risk of a composite cardiovascular outcome that was lower than the risk among those who were treated for the infarct-related artery only. This finding was mainly supported by a reduction in subsequent revascularizations. (Funded by Maasstad Cardiovascular Research and others; Compare-Acute ClinicalTrials.gov number, NCT01399736 .).
Smits et al. (Sat,) studied this question.