Why the study?
Does the addition of FFR-guided complete revascularization of non-infarct-related arteries in the acute setting reduce a composite cardiovascular outcome in patients with STEMI and multivessel disease who underwent primary PCI?
Does the addition of FFR-guided complete revascularization of non-infarct-related arteries in the acute setting reduce a composite cardiovascular outcome in patients with STEMI and multivessel disease who underwent primary PCI?
In STEMI patients with multivessel disease, performing FFR-guided complete revascularization in the acute setting reduces composite cardiovascular outcomes, primarily by decreasing the need for subsequent revascularizations.
Supports FFR-guided complete revascularization in acute STEMI with multivessel disease; challenges prior low-certainty evidence against benefit.
In patients with STEMI and multivessel disease who underwent primary PCI of an infarct-related artery, the addition of FFR-guided complete revascularization of non-infarct-related arteries in the acute setting resulted in a risk of a composite cardiovascular outcome that was lower than the risk among those who were treated for the infarct-related artery only. This finding was mainly supported by a reduction in subsequent revascularizations. (Funded by Maasstad Cardiovascular Research and others; Compare-Acute ClinicalTrials.gov number, NCT01399736 .).
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Smits et al. (2017) studied this question.
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