Identifies NAD(P)H oxidases, eNOS uncoupling, and PKC signaling as key mediators of vascular superoxide production and endothelial dysfunction in human diabetes.
These observations suggest important roles for NAD(P)H oxidases, endothelial NO synthase uncoupling, and protein kinase C signaling in mediating increased vascular superoxide production and endothelial dysfunction in human diabetes mellitus.
Guzik et al. (Tue,) studied this question.
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