Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus
Population
Humans with diabetes mellitus
Design
Other
Authors
Discussion
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Member takes
Implication
May guide targeted inhibitor development for diabetic vasculopathy; leaves open clinical translation pending in vivo trials.
Structured PICO
P
Population
Humans with diabetes mellitus
O
Outcome
Vascular superoxide production and endothelial dysfunctionsurrogate
Identifies NAD(P)H oxidases, eNOS uncoupling, and PKC signaling as key mediators of vascular superoxide production and endothelial dysfunction in human diabetes.
Cite This Study
Guzik et al. (2002) studied this question.