Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
Why the study?
Does angiotensin II infusion increase vascular superoxide production and alter vasomotor tone in rats compared to norepinephrine-induced hypertension?
Population
Rats
Comparison
Angiotensin II infusion (0.7 mg/kg per d) vs Norepinephrine (NE) infusion (2.75 mg/kg per d)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Points to AT1-mediated oxidative stress in experimental hypertension; leaves open human translation and clinical relevance.
Structured PICO
Does angiotensin II infusion increase vascular superoxide production and alter vasomotor tone in rats compared to norepinephrine-induced hypertension?
P
Population
Rats
I
Intervention
Angiotensin II infusion (0.7 mg/kg per d)
C
Comparator
Norepinephrine (NE) infusion (2.75 mg/kg per d)
O
Outcome
Vascular superoxide (.O2-) production (assessed by lucigenin chemiluminescence) and vascular relaxations to acetylcholine, calcium ionophore A23187, and nitroglycerinsurrogate
Angiotensin II-induced hypertension uniquely increases vascular superoxide production via NADH/NADPH oxidase activation, impairing vasomotor tone through an AT1 receptor-mediated mechanism.
Cite This Study
Rajagopalan et al. (1996) studied this question.