What question did this study set out to answer?

To investigate the variation of stromal tumor infiltrating lymphocytes (sTILs) across different breast cancer grades and molecular subtypes, particularly their correlation with aggressive features.

April 10, 2026

Comparative Analysis of Stromal Tumor Infiltrating Lymphocytes in Various Grades and Molecular Subtypes of Breast Carcinoma

Key Points

To investigate the variation of stromal tumor infiltrating lymphocytes (sTILs) across different breast cancer grades and molecular subtypes, particularly their correlation with aggressive features.
Conducted a comparative analysis of sTILs in various grades and molecular subtypes of breast carcinoma.
Assessed correlation between sTIL levels and pathological features of the tumors.
Evaluated the implications of standardized sTIL assessments on routine pathological reporting.
sTILs show significant variability among breast cancer subtypes, especially noted in triple-negative breast cancer.
High-grade tumors exhibit a stronger presence of sTILs compared to lower-grade ones.
Incorporation of sTIL assessment in routine reporting could enhance identification of immune-active tumors.

Abstract

sTILs vary markedly across breast cancer subtypes and correlate with aggressive pathological features, particularly TNBC, high-grade, hormone receptor negativity, and high proliferative index. Incorporating standardized sTIL assessment into routine reporting may help identify tumors with active immune microenvironments.

Comparative Analysis of Stromal Tumor Infiltrating Lymphocytes in Various Grades and Molecular Subtypes of Breast Carcinoma

Key Points

Abstract

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