What question did this study set out to answer?

To evaluate the global prevalence of neuromyelitis optica spectrum disorder and compare it with regional data from Brazil.

April 10, 2026

Global Prevalence of Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis with New Data from Rio de Janeiro, Brazil

Key Points

To evaluate the global prevalence of neuromyelitis optica spectrum disorder and compare it with regional data from Brazil.
Conducted a global systematic review on NMOSD prevalence
Performed a regional population-based analysis in southeastern Brazil
Executed a meta-analysis to synthesize global and local prevalence data
Found that NMOSD prevalence in Brazil exceeds the global pooled estimate
Confirmed higher prevalence rates in the Americas
Observed a correlation between prevalence and African ancestral backgrounds

Abstract

This study provides an integrated evaluation of NMOSD prevalence through a global systematic review, a regional population-based analysis in southeastern Brazil, and a meta-analysis, demonstrating that prevalence in this region is higher than the global pooled estimate and consistent with the higher prevalence observed in the Americas, particularly in populations with substantial African ancestral backgrounds.

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Cite This Study

Alvarenga et al. (Tue,) studied this question.

synapsesocial.com/papers/69d894ad6c1944d70ce059f3 https://doi.org/https://doi.org/10.1159/000551533

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