What question did this study set out to answer?

The research aims to explore innovative peptidomimetics that can prevent the aggregation of hIAPP, linking this process to T2DM.

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April 10, 2026

Intervention of hIAPP amyloid aggregation by smart posttransmuting anti-amyloidogenic peptidomimetics

Key Points

The research aims to explore innovative peptidomimetics that can prevent the aggregation of hIAPP, linking this process to T2DM.
Investigated various peptidomimetics for their effects on hIAPP aggregation.
Utilized in vitro models to simulate amyloid formation.
Analyzed the efficacy of selected compounds on amyloid suppression.
Certain peptidomimetics demonstrated a significant reduction in hIAPP aggregation.
The findings suggest a promising avenue for therapeutic intervention in T2DM.

Abstract

hIAPP, human islet amyloid polypeptide, aggregates have been implicated in the development of type 2 diabetes mellitus (T2DM). As a prelude to developing a potential cure for T2DM, researchers worldwide...

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Authors

Altaf Hussain Kawa

Indian Institute of Technology Guwahati

Biswadeepak Satapathy

Indian Institute of Technology Guwahati

Shinjini Bhattacharya

Indian Institute of Technology Guwahati

Journals

Journal of Materials Chemistry B

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Cite this study

Kawa et al. (Thu,) studied this question.

synapsesocial.com/papers/69d895a86c1944d70ce06c32 — DOI: https://doi.org/10.1039/d5tb02851e

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease· 1995 · 361 citations
Protein Misfolding, Functional Amyloid, and Human Disease· 2006 · 6,406 citations
Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.· 1999 · 490 citations
Folding proteins in fatal ways· 2003 · 1,420 citations
The Future of Peptide‐based Drugs· 2012 · 1,951 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease· 1995 · 361 citations
Protein Misfolding, Functional Amyloid, and Human Disease· 2006 · 6,406 citations
Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.· 1999 · 490 citations
Folding proteins in fatal ways· 2003 · 1,420 citations
The Future of Peptide‐based Drugs· 2012 · 1,951 citations

Intervention of hIAPP amyloid aggregation by smart posttransmuting anti-amyloidogenic peptidomimetics

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider