Systems genetics identified Abcc6 as a novel genetic contributor to stress-induced cardiac fibrosis in mice.
Genetic variants significantly contribute to the phenotypic heterogeneity of stress-induced cardiomyopathy. Systems genetics is an effective approach to identify genes and pathways underlying the specific pathological features of cardiomyopathies. Abcc6 is a previously unrecognized player in the development of stress-induced cardiac fibrosis.
Rau et al. (Sat,) studied this question.