Palladium-Catalyzed Fluoroalkylative C7–H Cyclization of Indoles to Lilolidines

Key Points

• This research focuses on developing a new method for C7-H functionalization of indoles using palladium and fluoroalkyl radicals.
• Developed a palladium-catalyzed strategy for C7-H functionalization/annulation
• Utilized unactivated olefin-tethered N-alkyl indoles
• Employed bromofluoroalkyl reagents for the reaction
• Successfully achieved direct C7-H functionalization of indoles
• Demonstrated efficient access to lilolidines
• Showed the potential of the method for broader applications in organic synthesis