Are elevated plasma total tau levels associated with cognitive decline and risk of mild cognitive impairment or dementia?
Elevated plasma total tau levels are independently associated with cognitive decline, regardless of brain Aβ levels.
These results suggest that elevated plasma total tau levels are associated with cognitive decline, but the results differ based on cognitive status and the duration of follow-up. The association between plasma total tau levels and cognition is independent of elevated brain Aβ.
Mielke et al. (Mon,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: