Why the study?
Are elevated plasma total tau levels associated with cognitive decline and risk of mild cognitive impairment or dementia?
Are elevated plasma total tau levels associated with cognitive decline and risk of mild cognitive impairment or dementia?
Elevated plasma total tau levels are independently associated with cognitive decline, regardless of brain Aβ levels.
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May support plasma tau monitoring beyond Aβ; leaves open clinical utility for MCI/dementia risk stratification.
Mielke et al. (2017) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: