The Spectrum of Symptoms and QT Intervals in Carriers of the Gene for the Long-QT Syndrome

Structured PICO

Does the use of DNA markers improve the accurate diagnosis of long-QT syndrome compared to QTc interval measurement in affected families?

Population

Families affected by the long-QT syndrome / carriers of the gene for the Long-QT syndrome

Intervention

DNA markers for genetic diagnosis

Comparator

Measurement of the QTc interval

Outcome

Accurate diagnosis of long-QT syndrome

DNA markers provide a more accurate genetic diagnosis of long-QT syndrome than QTc interval measurement, identifying asymptomatic gene carriers.

Abstract

In families affected by the long-QT syndrome, measurement of the QTc interval may not permit an accurate diagnosis. DNA markers make it possible to make a genetic diagnosis in some families, but not all gene carriers have symptoms.

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Cite This Study

Vincent et al. (Thu,) studied this question.

synapsesocial.com/papers/69dd595a0644c7b49d40d0d6 https://doi.org/https://doi.org/10.1056/nejm199209173271204

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