Does the use of DNA markers improve the accurate diagnosis of long-QT syndrome compared to QTc interval measurement in affected families?
Families affected by the long-QT syndrome / carriers of the gene for the Long-QT syndrome
DNA markers for genetic diagnosis
Measurement of the QTc interval
Accurate diagnosis of long-QT syndrome
DNA markers provide a more accurate genetic diagnosis of long-QT syndrome than QTc interval measurement, identifying asymptomatic gene carriers.
In families affected by the long-QT syndrome, measurement of the QTc interval may not permit an accurate diagnosis. DNA markers make it possible to make a genetic diagnosis in some families, but not all gene carriers have symptoms.
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G. Michael Vincent
Intermountain Healthcare
Katherine W. Timothy
Electrophysiology
Mark Leppert
Institute for Systems Biology
New England Journal of Medicine
Howard Hughes Medical Institute
LDS Hospital
Institute of Human Genetics
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Vincent et al. (Thu,) studied this question.
synapsesocial.com/papers/69dd595a0644c7b49d40d0d6 — DOI: https://doi.org/10.1056/nejm199209173271204
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