January 1, 2015Open Access

Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome

Structured PICO

P

Population

Rats post-myocardial infarction (MI)

O

Outcome

Cardiac remodeling (including cardiac fibroblast phenotypic transversion, increased collagen and extracellular matrix secretion)surrogate

The CaSR/NLRP3 inflammasome in M1 macrophages, but not M2 macrophages, contributes to post-MI cardiac remodeling in rats.

Abstract

We suggest that the CaSR/NLRP3 inflammasome plays an essential role via the PLC-IP3 pathway in M1MΦ to promote cardiac remodeling post-MI in rats, including accelerated cardiac fibroblast phenotypic transversion, increased collagen and extracellular matrix (ECM) secretion; however, the CaSR/NLRP3 inflammasome does not play a role in this process in M2MΦ.

Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome

Structured PICO

Abstract

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