The CaSR/NLRP3 inflammasome in M1 macrophages, but not M2 macrophages, contributes to post-MI cardiac remodeling in rats.
Hypothesis-generating for M1-specific CaSR/NLRP3 targeting post-MI; leaves open translation to human cardiac remodeling.
We suggest that the CaSR/NLRP3 inflammasome plays an essential role via the PLC-IP3 pathway in M1MΦ to promote cardiac remodeling post-MI in rats, including accelerated cardiac fibroblast phenotypic transversion, increased collagen and extracellular matrix (ECM) secretion; however, the CaSR/NLRP3 inflammasome does not play a role in this process in M2MΦ.
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Liu et al. (2015) studied this question.
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