Does adherence and persistence with direct oral anticoagulants differ between anticoagulant-naïve and anticoagulant-experienced adults with atrial fibrillation?
Real-world adherence and persistence to DOACs in adults with atrial fibrillation decline over time and are particularly suboptimal in anticoagulant-naïve patients, highlighting a need for targeted patient education.
Medication adherence and persistence with DOACs declined over time and both were suboptimal and lower (at 6 and 12 mo postindex) in AC-naïve compared to AC-experienced patients. These findings can help target future strategies or interventions for patient education and long-term AC management especially in those patients naïve to DOAC therapy. Future investigation should examine potential reasons for differences in DOAC adherence and persistence between AC-experienced versus AC-naïve patients and the implications for patient outcomes.
Manzoor et al. (Fri,) studied this question.