What does this research mean for the field?

High expression of PAPP-A predicts poor prognosis in estrogen receptor-positive (ER+) breast cancer and is correlated with the activation of the IGF-1/IGF-1R pathway. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to investigate the relationship between PAPP-A expression and prognosis in estrogen receptor-positive breast cancer.

April 15, 2026Open Access

High Expression of PAPP ‐A Predicts Poor Outcomes in Oestrogen Receptor‐Positive Breast Cancer Patients

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Key Points

This research aims to investigate the relationship between PAPP-A expression and prognosis in estrogen receptor-positive breast cancer.
Analyzed PAPP-A expression levels in breast cancer tissues
Correlated PAPP-A levels with clinical outcomes
Assessed activation of the IGF-1/IGF-1R pathway
Higher PAPP-A expression is linked to worse outcomes in ER-positive breast cancer
PAPP-A correlates with increased activation of the IGF-1/IGF-1R pathway

Abstract

High expression of PAPP-A is associated with poor prognosis in ER+ breast cancer and correlates with IGF-1/IGF-1R pathway activation.

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Discussion

Cite this study

Mabruk et al. (Wed,) studied this question.

synapsesocial.com/papers/69df2abce4eeef8a2a6afb0b — DOI: https://doi.org/10.1002/cam4.71815

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Authors

Zeanap Mabruk

Edinburgh Cancer Research

Esme Bullock

Edinburgh Cancer Research

Xue Ming Xiao

University of Electronic Science and Technology of China

Journals

Cancer Medicine

Actions

Institutions

Aarhus University

University of Electronic Science and Technology of China

Edinburgh Cancer Research

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

High Expression of PAPP ‐A Predicts Poor Outcomes in Oestrogen Receptor‐Positive Breast Cancer Patients

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Also consider