What does this research mean for the field?

High expression of PAPP-A predicts poor prognosis in estrogen receptor-positive (ER+) breast cancer and is correlated with the activation of the IGF-1/IGF-1R pathway. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to investigate the relationship between PAPP-A expression and prognosis in estrogen receptor-positive breast cancer.

April 15, 2026Cancer Medicine0 citationsOpen Access

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High Expression of PAPP ‐A Predicts Poor Outcomes in Oestrogen Receptor‐Positive Breast Cancer Patients

ZMZeanap MabrukEdinburgh Cancer Research EBEsme BullockEdinburgh Cancer Research XXXue Ming XiaoUniversity of Electronic Science and Technology of China

Key Points

This research aims to investigate the relationship between PAPP-A expression and prognosis in estrogen receptor-positive breast cancer.
Analyzed PAPP-A expression levels in breast cancer tissues
Correlated PAPP-A levels with clinical outcomes
Assessed activation of the IGF-1/IGF-1R pathway
Higher PAPP-A expression is linked to worse outcomes in ER-positive breast cancer
PAPP-A correlates with increased activation of the IGF-1/IGF-1R pathway

Abstract

High expression of PAPP-A is associated with poor prognosis in ER+ breast cancer and correlates with IGF-1/IGF-1R pathway activation.

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High Expression of PAPP ‐A Predicts Poor Outcomes in Oestrogen Receptor‐Positive Breast Cancer Patients

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Abstract

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