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Investigation of iterative deconvolution in 177Lu-SPECT imaging for lesion dosimetry | Synapse

April 15, 2026Open Access

Investigation of iterative deconvolution in 177Lu-SPECT imaging for lesion dosimetry

Key Points

To explore the effectiveness of iterative deconvolution for improving lesion dosimetry in 177Lu-SPECT imaging.
Compared organ reception (OR) with lesion reference distribution (LRD) methods.
Analyzed the impact of these methods on absorbed dose (AD) across various radiopharmaceuticals and lesion locations.
Evaluated the necessity of implementing image-based spill-over correction techniques.
AD increased when LRD was applied compared to OR, regardless of the radiopharmaceutical.
LRD showed potential for reducing overall uncertainty in lesion absorbed doses.

Abstract

OR + LRD increased AD compared to OR, independent of administered radiopharmaceutical and lesion location. This study suggests that implementing LRD may be a promising option for image-based spill-over correction in 177Lu-SPECT based dosimetry. Further studies are necessary to investigate the effect of different PVC methods, such as LRD or phantom-based correction factors, on overall uncertainty of lesion ADs.

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Cite This Study

Ells et al. (Mon,) studied this question.

synapsesocial.com/papers/69df2cb9e4eeef8a2a6b1e77 https://doi.org/https://doi.org/10.1186/s40658-026-00865-5

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