Does a high dose of dexmedetomidine reduce the minimum alveolar concentration of isoflurane in patients having surgery?
High-dose dexmedetomidine significantly reduces the minimum alveolar concentration of isoflurane required during surgery.
The MAC of isoflurane in the control group was lower than that reported previously in similar patients having surgery, probably due to anesthesia induction with thiopental and alfentanil. Nevertheless, with the high dose of dexmedetomidine, the MAC of isoflurane was still 47% less than that without dexmedetomidine.
Aantaa et al. (Thu,) studied this question.