Does hypoglycemia alter brain activation during working memory in patients with type 1 diabetes compared to controls?
Patients with type 1 diabetes require higher levels of brain activation to achieve the same cognitive performance during hypoglycemia, suggesting reduced cerebral efficiency.
BOLD activation was increased and deactivation was decreased in type 1 diabetic versus control subjects during hypoglycemia. This higher level of brain activation required by type 1 diabetic subjects to attain the same level of cognitive performance as control subjects suggests reduced cerebral efficiency in type 1 diabetes.
Bolo et al. (Sat,) studied this question.