Why the study?
Does hypoglycemia alter brain activation during working memory in patients with type 1 diabetes compared to controls?
Does hypoglycemia alter brain activation during working memory in patients with type 1 diabetes compared to controls?
Patients with type 1 diabetes require higher levels of brain activation to achieve the same cognitive performance during hypoglycemia, suggesting reduced cerebral efficiency.
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May indicate reduced cerebral efficiency in T1D during hypoglycemia; hypothesis-generating and should not yet change practice.
BOLD activation was increased and deactivation was decreased in type 1 diabetic versus control subjects during hypoglycemia. This higher level of brain activation required by type 1 diabetic subjects to attain the same level of cognitive performance as control subjects suggests reduced cerebral efficiency in type 1 diabetes.
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Bolo et al. (2011) studied this question.
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