Ferulic and p -coumaric acid derivatives as dual EGFR-VEGFR2 inhibitors: design, semi-synthesis, and biological investigations

Key Points

• The aim is to develop ferulic and p-coumaric acid derivatives that inhibit EGFR and VEGFR2 for breast cancer treatment.
• Designed ferulic and p-coumaric acid derivatives
• Synthesized compounds using semi-synthesis
• Evaluated cytotoxicity through in vitro and in vivo assays
• Compounds exhibited potent cytotoxic effects on breast cancer cells
• Induced apoptosis in tested breast cancer models
• Demonstrated effective dual inhibition of EGFR and VEGFR2