Visible-light-induced dearomative amidodifluoroalkylation of indole derivatives to access C3a-difluoroalkyl pyrroloindolines

Key Points

• The research aims to develop a new method for synthesizing C3a-difluoroalkyl pyrroloindolines from indole derivatives.
• Utilized visible-light to activate amidyl radicals.
• Performed reactions with indole derivatives and difluorinated silanes.
• Analyzed the reaction products to confirm the synthesis of pyrroloindolines.
• Successfully synthesized C3a-difluoroalkyl pyrroloindolines.
• Demonstrated that the method is effective under mild conditions.
• Showed that fluorinated compounds can enhance bioactivity in natural products.