Visible-light-induced dearomative amidodifluoroalkylation of indole derivatives to access C3a-difluoroalkyl pyrroloindolines

C Li; Jingjie Yang; Zewei Xie; Haijian Wu; Manman Sun; Zhiming Wang; Jianguo Yang; Xiaolei Zhu

doi:10.1039/d6qo00308g

January 1, 2026Organic Chemistry Frontiers

Visible-light-induced dearomative amidodifluoroalkylation of indole derivatives to access C3a-difluoroalkyl pyrroloindolines

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Key Points

The research aims to develop a new method for synthesizing C3a-difluoroalkyl pyrroloindolines from indole derivatives.
Utilized visible-light to activate amidyl radicals.
Performed reactions with indole derivatives and difluorinated silanes.
Analyzed the reaction products to confirm the synthesis of pyrroloindolines.
Successfully synthesized C3a-difluoroalkyl pyrroloindolines.
Demonstrated that the method is effective under mild conditions.
Showed that fluorinated compounds can enhance bioactivity in natural products.

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Implication

In this study, amidyl radical-mediated dearomatization improves access to pyrroloindolines, suggesting a new method for creating complex medicinal compounds.

Abstract

Fluorinated heterocycles is a privileged structural motif that is widely present in many natural products and pharmaceutical compounds. Herein, we report an amidyl radical-mediated dearomatization of indoles with difluorinated silyl...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69e07de52f7e8953b7cbed41 https://doi.org/10.1039/d6qo00308g

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Visible-light-induced dearomative amidodifluoroalkylation of indole derivatives to access C3a-difluoroalkyl pyrroloindolines

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Visible-light-induced dearomative amidodifluoroalkylation of indole derivatives to access C3a-difluoroalkyl pyrroloindolines

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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