What question did this study set out to answer?

The research aims to evaluate the effectiveness of gamma knife radiosurgery (GKRS) in treating pediatric brain tumors based on tumor histology and age.

April 16, 2026Open Access

Gamma knife radiosurgery in pediatric neuro-oncology: histology-specific outcomes and age-adapted procedural strategies

Key Points

The research aims to evaluate the effectiveness of gamma knife radiosurgery (GKRS) in treating pediatric brain tumors based on tumor histology and age.
Assessment of GKRS outcomes in pediatric patients with various brain tumor histologies.
Comparison between benign, low-grade, and aggressive tumor responses to GKRS.
Development of age-adapted procedural strategies for safer application.
GKRS effectively controls selected benign and low-grade tumors in pediatric patients.
Aggressive histologies show higher rates of progression and mortality post-GKRS.
Histology-based patient selection improves overall treatment strategies.

Abstract

GKRS provides durable local control in selected benign and low-grade pediatric brain tumors; however, outcomes remain poor in aggressive histologies, with high rates of progression and mortality. These findings highlight the importance of histology-based patient selection and integration of GKRS into multimodal treatment strategies. Age-adapted procedural approaches facilitate safe application in pediatric patients.

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