Gamma knife radiosurgery in pediatric neuro-oncology: histology-specific outcomes and age-adapted procedural strategies

GKRS provides durable local control in selected benign and low-grade pediatric brain tumors; however, outcomes remain poor in aggressive histologies, with high rates of progression and mortality. These findings highlight the importance of histology-based patient selection and integration of GKRS into multimodal treatment strategies. Age-adapted procedural approaches facilitate safe application in pediatric patients.