Does stimulating glucose oxidation via targeting PDH or MCD decrease infarct size in models of acute myocardial infarction and reperfusion injury?
Optimizing myocardial metabolism by stimulating glucose oxidation reduces infarct size, representing a potential novel therapeutic approach for ischemic heart disease.
These findings demonstrate that stimulating glucose oxidation via targeting either PDH or MCD decreases the infarct size, validating the concept that optimizing myocardial metabolism is a novel therapy for ischaemic heart disease.
Ussher et al. (Wed,) studied this question.
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