SIRT1 plays a critical role in maintaining the viability of Yak Sertoli cells by regulating mitochondrial biogenesis via activating the PGC-1α-NRF-1-TFAM pathway

Key Points

• The study aims to explore SIRT1's regulatory role in yak Sertoli cells and its impact on mitochondrial functions.
• Investigated the role of SIRT1 in yak Sertoli cells
• Examined the PGC-1α-NRF-1-TFAM pathway
• Performed assays to assess cell viability and mitochondrial function
• SIRT1 positively regulates mitochondrial biogenesis in Sertoli cells
• Activation of the PGC-1α-NRF-1-TFAM pathway was observed
• Enhanced viability of yak Sertoli cells was linked to SIRT1 activity