Differentiating IgG4-related Sclerosing Cholangitis from Primary Sclerosing Cholangitis: A Comprehensive Systematic Review and Meta-analysis of Diagnostic Features

Key Points

• The aim is to distinguish between IgG4-related sclerosing cholangitis and primary sclerosing cholangitis based on diagnostic features.
• Conducted a systematic review and meta-analysis
• Analyzed clinical, radiographic, and histological features
• Evaluated the impact of elevated IgG4 levels and history of pancreatitis
• IgG4-SC and PSC share similar clinical and radiographic features
• A history of unusual pancreatitis is noted in patients with IgG4-SC
• Elevated IgG4 levels can indicate a need for specific radiographic assessments