Meta-analysis differentiates IgG4-related sclerosing cholangitis and primary sclerosing cholangitis, suggesting diagnostic features.
Our meta-analysis shows that IgG4-SC and PSC present with similar clinical and radiographic features and possibly comparable histology. A history of unusual pancreatitis and elevated IgG4 (serum or tissue) prompt assessment for more specific radiographic features which if present warrant a therapeutic treatment trial.
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Wang et al. (2026) studied this question.
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