Fucoidan Alleviates Kidney Fibrosis by Shaping the Gut Microbiota and Modulating Tryptophan Metabolism

Key Points

• The aim is to investigate how fucoidan influences kidney fibrosis through gut microbiota alteration and tryptophan metabolism.
• Utilized animal models of chronic kidney disease
• Administered fucoidan to measure effects on renal fibrosis
• Analyzed changes in gut microbiota composition
• Evaluated tryptophan metabolic pathways
• Fucoidan significantly reduced kidney fibrosis markers
• Altered gut microbiota profile favorably
• Enhanced tryptophan metabolism pathways related to kidney health