OCT demonstrated moderate diagnostic efficiency in identifying hemodynamically severe coronary stenoses (AUC 0.74; 95% CI 0.61-0.84), with low specificity precluding its use as an FFR substitute.
Observational (n=56)
Does optical coherence tomography accurately identify hemodynamically severe coronary stenoses compared to fractional flow reserve in patients with intermediate angiographic severity?
OCT has moderate diagnostic efficiency for identifying functionally significant coronary stenoses, slightly outperforming IVUS in small vessels, but its low specificity precludes it from substituting FFR.
Effect estimate: AUC 0.74 (95% CI 0.61 to 0.84)
OBJECTIVES: The study sought to assess the diagnostic efficiency of optical coherence tomography (OCT) in identifying hemodynamically severe coronary stenoses as determined by fractional flow reserve (FFR). Concomitant OCT and intravascular ultrasound (IVUS) area measurements were performed in a subgroup of patients to compare the diagnostic efficiency of both techniques. BACKGROUND: The value of OCT to determine stenosis severity remains unsettled. METHODS: Sixty-one stenoses with intermediate angiographic severity were studied in 56 patients. Stenoses were labeled as severe if FFR ≤0.80. OCT interrogation was performed in all cases, with concomitant IVUS imaging in 47 cases. RESULTS: Angiographic stenosis severity was 50.9 ± 8% diameter stenosis with 1.28 ± 0.3 mm minimal lumen diameter. FFR was ≤0.80 in 28 (45.9%) stenoses. An overall moderate diagnostic efficiency of OCT was found (area under the curve AUC: 0.74; 95% confidence interval CI: 0.61 to 0.84), with sensitivity/specificity of 82%/63% associated with an optimal cutoff value of 1.95 mm(2). Comparison of the results in patients with simultaneous IVUS and OCT imaging revealed no significant differences in the diagnostic efficiency of OCT (AUC: 0.70; 95% CI: 0.55 to 0.83) and IVUS (AUC. 0.63; 95% CI: 0.47 to 0.77; p = 0.19). Sensitivity/specificity for IVUS was 67%/65% for an optimal cutoff value of 2.36 mm(2). In the subgroup of small vessels (reference diameter <3 mm) OCT showed a significantly better diagnostic efficiency (AUC: 0.77; 95% CI: 0.60 to 0.89) than IVUS (AUC: 0.63; 95% CI: 0.46 to 0.78) to identify functionally significant stenoses (p = 0.04). CONCLUSIONS: OCT has a moderate diagnostic efficiency in identifying hemodynamically severe coronary stenoses. Although OCT seems slightly superior to IVUS for this purpose (particularly in vessels <3 mm), its low specificity precludes its use as a substitute of FFR for functional stenosis assessment.
Gonzalo et al. (Thu,) conducted a observational in Coronary stenoses with intermediate angiographic severity (n=56). Optical coherence tomography (OCT) vs. Fractional flow reserve (FFR) and Intravascular ultrasound (IVUS) was evaluated on Diagnostic efficiency (AUC) of OCT in identifying hemodynamically severe coronary stenoses (FFR ≤0.80) (AUC 0.74, 95% CI 0.61 to 0.84). OCT demonstrated moderate diagnostic efficiency in identifying hemodynamically severe coronary stenoses (AUC 0.74; 95% CI 0.61-0.84), with low specificity precluding its use as an FFR substitute.
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