Indirect Striatal Projection Neurons Drive a D2 Receptor‐Dependent Pathway to Dyskinesia and Dystonia

Key Points

• This research aims to explore the role of indirect-pathway D2 receptors in dyskinesia and dystonia during L-DOPA treatment.
• Experimental evidence collected through observation during L-DOPA treatment.
• Assessment of D2 receptor involvement in dyskinesia and dystonia.
• Indirect-pathway D2 receptors significantly contribute to dyskinesia expression.
• D2 agonist dependency is linked to the occurrence of dystonic features.