Indirect Striatal Projection Neurons Drive a D2 Receptor‐Dependent Pathway to Dyskinesia and Dystonia

Laura Andreoli; Teodor Nyman; Elena Espa; Johan Jakobsson; Osama F. Elabi; Maria Angela Cenci

doi:10.1002/mds.70299

April 20, 2026Movement DisordersOpen Access

Indirect Striatal Projection Neurons Drive a D2 Receptor‐Dependent Pathway to Dyskinesia and Dystonia

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Key Points

This research aims to explore the role of indirect-pathway D2 receptors in dyskinesia and dystonia during L-DOPA treatment.
Experimental evidence collected through observation during L-DOPA treatment.
Assessment of D2 receptor involvement in dyskinesia and dystonia.
Indirect-pathway D2 receptors significantly contribute to dyskinesia expression.
D2 agonist dependency is linked to the occurrence of dystonic features.

Implication

Experimental evidence shows indirect-pathway d2 receptors drive dyskinesia in L-DOPA treatment, implying new insights for therapy.

Abstract

We provide experimental evidence that indirect-pathway D2 receptors significantly contribute to the expression of dyskinesia during L-DOPA treatment and mediate D2 agonist-dependent dystonic features.

Discussion

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Cite This Study

Andreoli et al. (2026) studied this question.

synapsesocial.com/papers/69e8656e6e0dea528dde9f03 https://doi.org/10.1002/mds.70299

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Indirect Striatal Projection Neurons Drive a D2 Receptor‐Dependent Pathway to Dyskinesia and Dystonia

Key Points

Implication

Abstract

Discussion

Cite This Study

Indirect Striatal Projection Neurons Drive a D2 Receptor‐Dependent Pathway to Dyskinesia and Dystonia

Key Points

Implication

Abstract

Discussion

Cite This Study

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