Demonstrates that cardiac myocytes are an active source of IL-6 production in the setting of myocardial infarction and reperfusion.
Isolated cardiac myocytes produce IL-6 mRNA in response to several cytokines as well as postischemic cardiac lymph. In addition to its production by inflammatory cells, we demonstrate that IL-6 mRNA is induced in myocytes in the viable border zone of a myocardial infarct. The potential roles of IL-6 in cardiac myocytes in an infarct border are discussed.
Gwechenberger et al. (Tue,) studied this question.