Mechanical unloading of the heart induces active remodeling that involves simultaneous activation of both protein degradation (UPP) and synthesis (mTOR) pathways.
Atrophy of the heart, secondary to mechanical unloading, is associated with early activation of the UPP. The simultaneous activation of the mTOR pathway suggests active remodeling, involving both protein synthesis and degradation.
Razeghi et al. (Tue,) studied this question.